Recovery of reproductive endocrine function after orthotopic fetal ovarian allotransplantation in rats / 南方医科大学学报

<p><b>OBJECTIVE</b>To assess the recovery of the reproductive endocrine function in rats following orthotopic transplantation of fetal ovarian allograft.</p><p><b>METHODS</b>Ninety female SD rats (50-60 days old) were randomized into graft recipient group (n=50), positive control group (n=20), and negative control group (n=20) to receive orthotopic transplantation of fetal (17-19 gestational days) ovaries following bilateral oophorectomy, sham abdominal surgery, and bilateral oophorectomy, respectively. At 45 days after the surgeries, serum estradiol and progesterone levels were measured and the ovaries were removed for evaluation of the ovarian volume and follicle development.</p><p><b>RESULTS</b>On day 45 after the operations, the estradiol or progesterone levels showed no significant difference between the recipient group and positive control group (P>0.05), but both were significantly lowered in the negative control group (P<0.05). The ovarian volume was comparable between the recipient group and positive control group (P>0.05), and optical microscopy showed follicles in different stages of development and formation of corpus luteum in the ovaries in both groups.</p><p><b>CONCLUSION</b>Fetal rat ovary allografts can develop into functional ovaries capable of ovulation to restore the reproductive endocrine function of recipient female rats.</p>

Hysteroscopic treatment of women with previous cesarean scar defect / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the effects of hysteroscopic treatment of women with previous cesarean scar defect (PCSD).</p><p><b>METHODS</b>From May 2006 to October 2008, 12 patients with PCSD were diagnosed and treated hysteroscopically in our hospital, all of them were successful followed-up for one year postoperatively, and their clinical data were analyzed.</p><p><b>RESULTS</b>All 12 hysteroscopic procedures were completed successfully, and there were no surgical complications. Nine patients with longer periods and 1 patient with intermenstrual spotting preoperatively remained asymptomatic after hysteroscopic surgery, and 1 patient with longer periods and infertility experienced normal periods, while remained infertility, and the remaining 1 patient complaining postcoital bleeding preoperatively had recurrence of the bleeding.</p><p><b>CONCLUSION</b>Hysteroscopic surgery of women with PCSD was minimally invasive and effective.</p>